Book Title: Biomolecular Networks -- Computational Methods and Applications in Bioinformatics and Systems Biology

Authors: Luonan Chen, Rui-Sheng Wang, Xiang-Sun Zhang

To be published in the Wiley Book Series On Bioinformatics in 2008

Background:

With the sequencing of several main genomes finished, we have entered into an era of post-genomics or systems biology, and high-throughput experimental methods in molecular biology have resulted in enormous amount of data, which can be used to study molecular networks in living organisms. It has been recognized that a complicated living organism cannot be fully understood by merely analyzing individual components. It is the interactions of those components or molecular networks that are ultimately responsible for an organism's form and functions. To elucidate the essential principles or fundamental mechanisms of cellular systems, study on biomolecular networks is increasingly attracting much attention from communities of both biology and engineering. A major challenge is to investigate how cellular systems facilitate biological functions or achieve lives by various 'interactions' (networks or pathways) between genes, proteins, and metabolities. In other words, with these molecular networks formed by the 'interactions'of biomolecules, it is highly demanded that mathematicians and scientists in computer sciences provide computational tools for biologists to reveal the essential biological mechanisms from a system perspective.


Tentative Contents:

Systems biology and bioinformatics, focusing on various biomolecular networks and other subjects,  is an emerging area as an intersection between mathematics, computer science and biology. This book will cover extensive contents or topics on inferring and analyzing biomolecular networks in cellular systems based on available data in a comprehensive manner, in particular stressing on the aspects of networks, systems and engineering. Also the objective of this book is to facilitate biologists who are interested in investigating biology from a system perspective and also provides a detailed introduction of molecular networks for the other researchers who intend to study biology from a science and technology perspective. The book, based on authors' rich research works and experiences in biomolecular networks covers various topics related to biomolecular networks including latest trends.
 
Table of Contents:

Chapter 1. Introduction

Chapter 2.  Reconstruction of  Gene Regulatory Networks

Chapter 3. Reconstruction of Transcriptional Regulatory Network

Chapter 4. Inferrence of Protein-Protein Interaction Networks

Chapter 5. Indentification of Signal Transduction Pathways from PPI networks

Chapter 6. Function Prediction Based on Protein Interaction Networks

Chapter 7. Metabolic Networks: Reconstruction and Analysis

Chapter 8. Comparison of Biomolecular Networks

Chapter 9.  Topology Structure of Biomolecular Networks

Chapter 10. Network-based Protein Structural Analysis

Chapter 11 Integration of Heterogeneous Data and Biological  networks

Chapter 12. Other Topics and New Trends


Closely related articles can be found at
http://intelligent.eic.osaka-sandai.ac.jp/chenen/publication.htm